The overall goal of the IDAD Core is to provide expertise, facilities, services, and training in the area of HTS
assay design, development, validation, small and large-scale screening for organism (cell) based or biochemical
infectious disease targets. Assay development and performing high-throughput screening for infectious disease
targets can be very similar to other biological and disease targets; however, there are often specific biological
hazards associated with infectious disease targets that can require special consideration and conditions. This
core will build upon current assets and expand the current capabilities by providing enabling expertise and
dedicated attention of a core director and a technician to the community of infectious disease scientists and their
biologically- and disease-relevant targets. Core staff will facilitate design, development and validation of assays
suitable for automated high-throughput chemical screening. They will also facilitate small- or large-scale
screening of compounds (at KU or external sources). The expected outcomes of this core and associated efforts
are well developed and validated assays suitable for automated large-scale screening that can be performed
internally or externally. Hits generated through successful assay development and limited- or large-scale
screening efforts will be directed into Core C and Core D to identify lead compounds for use as molecular probes
and pre-therapeutics for infectious diseases. The expertise and resources will also enable investigators to
develop competitive proposals in response to NIH funding opportunities.


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